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Published on: May 14, 2013
Lysis of intravascular thrombus prior to coronary stenting using the dispatch infusion catheter
R A Kerensky1, E A Franco, B D Bertolet
1Section of Cardiology, University of Florida, Shands Hospital, Gainesville 32610-0277, USA.
Insights
Coronary stent placement is often contraindicated with thrombus. This study shows lysis of intracoronary thrombus using the Dispatch infusion catheter is feasible and safe before stenting.
Area of Science:
- Interventional Cardiology
- Vascular Medicine
Background:
- Angiographic thrombus historically contraindicates coronary stent placement.
- Effective thrombus management is crucial for successful percutaneous coronary intervention.
Observation:
- This report details four patients with angiographic thrombus.
- The Dispatch infusion catheter was used to deliver urokinase for thrombus lysis.
- Thrombus resolution was observed in all treated patients.
Findings:
- Successful lysis of intracoronary thrombus was achieved in all four patients using the Dispatch catheter and urokinase.
- Excellent angiographic outcomes were noted post-coronary stenting.
- No complications were reported with this lysis technique.
Implications:
- Lysis of intracoronary thrombus with the Dispatch infusion catheter appears feasible and safe.
- Further clinical trials are warranted to evaluate its efficacy in reducing acute stent thrombosis.
- This technique may offer a new approach for stent deployment in patients with coronary thrombus.
Abstract:
The presence of angiographic evidence of thrombus is generally thought to be a contraindication to coronary stent placement. This report describes four patients in whom angiographic thrombus was lysed using the Dispatch infusion catheter prior to coronary stenting. Urokinase was infused via the Dispatch catheter with resolution of angiographic evidence of thrombus in all cases. No complications were encountered using this technique, and all patients had excellent angiographic results after stenting. We conclude that lysis of intracoronary thrombus using the Dispatch infusion catheter is feasible and appears safe in this small study. Further trials are needed to determine if this technique reduces the acute stent thrombosis rate compared to other techniques for stent deployment in the presence of angiographic evidence of thrombus.
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