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Proposal for use of a standard side effect scoring system in studies exploring Helicobacter pylori treatment regimens
W A de Boer1, J C Thys, T J Borody
1Sint Anna Hospital, Oss, The Netherlands.
Abstract:
Many antibiotic regimens for treating Helicobacter pylori infection are currently used in clinical trials. The reported side-effect profiles of similar anti-Helicobacter therapies vary widely due to the use of different scoring systems. Therefore side-effect data from separate studies cannot be compared. Only randomized controlled trials will show how side-effect profiles and tolerability really differ between regimens, but few such studies are available. Therefore a choice of treatment based on side-effect profile is not possible at present. We seek standardization of side-effect registration among investigators and propose a side-effect questionnaire which, if generally accepted, would make it possible to compare data between trials.
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