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Endothelin regulation of vascular tonus
1Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
General Pharmacology
|June 1, 1996
Abstract:
1. Following the identification of endothelin-1 (ET-1) in 1988, an increasing body of work has accumulated on this endothelium-derived vasoconstrictor peptide. 2. ET-1 may regulate the regional vascular tonus. 3. ET-1 may directly act on the underlying smooth muscle to increase the force in a paracrine manner. ET-1 may also act on the endothelium to release relaxing factors in an autocrine manner. In either case, both ETA and ETB receptors may be involved.