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Acquired growth hormone resistance in catabolic states
1University of Sheffield, Clinical Sciences Centre, Northern General Hospital.
Bailliere'S Clinical Endocrinology and Metabolism
|July 1, 1996
Abstract:
Catabolic patients are resistant to the actions of GH. This resistance is probably multifactorial in origin. It is likely that both the fasting state and circulating factors, possibly cytokines, are aetiological. Resistance or insensitivity is characterized by raised GH levels, low IGF-I levels and a reduced anabolic response to GH.