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Updated: Aug 30, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Structure and action of MIP (Mytilus inhibitory peptide)-related tetrapeptides synthesized with a multipeptide
M Ohtani1, Y Muneoka, N Kanemoto
1Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
Abstract:
Using a multipeptide synthesizer we synthesized 19 peptide libraries, each of which consisted of 19 MIP-related tetrapeptides, and isolated a number of peptides, which have an inhibitory effect on phasic contraction of the ABRM of Mytilus, from the libraries. To the present, the structures of about 30 species of the peptides were determined, and the peptides with the determined structures were synthesized. The structure and action of each synthetic peptide was compared with those of others to explain structure-activity relationship of MIPs.
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