Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Antral gastrin cell hyperfunction and Helicobacter pylori infection

B Annibale¹, G Rindi, G D'Ambra

¹Gastroenterology Unit, University La Sapienza Rome, Italy.

Alimentary Pharmacology & Therapeutics

|August 1, 1996

Summary

Helicobacter pylori infection may cause antral gastrin cell hyperfunction (AGCH), leading to duodenal ulcers. Eradicating H. pylori reduced gastrin levels and normalized G/D cell ratios in AGCH patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Adult eosinophilic esophagitis patients diagnosed by food impaction are paucisymptomatic at index gastroscopy.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2025

Same author

Chronic atrophic gastritis and dyspepsia: a forgotten link?

Expert review of gastroenterology & hepatology·2025

Same author

Italian guidelines for the management of adult individuals with overweight and obesity and metabolic comorbidities that are resistant to behavioral treatment.

Journal of endocrinological investigation·2024

Same author

Quality of endoscopic screening for colorectal cancer in Italy: A national survey.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2022

Same author

Diagnostic Accuracy of EndoFaster® and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study.

Gastroenterology research and practice·2021

Same author

Second primary neoplasms in patients with lung and gastroenteropancreatic neuroendocrine neoplasms: Data from a retrospective multi-centric study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2021

Area of Science:

Gastroenterology
Microbiology
Cell Biology

Background:

Antral gastrin cell hyperfunction (AGCH) is a rare cause of duodenal ulcers, characterized by non-tumoral hypergastrinemia and acid hypersecretion.
The specific triggers and mechanisms underlying AGCH remain incompletely understood.

Purpose of the Study:

To investigate the potential role of Helicobacter pylori (H. pylori) infection in the development of AGCH.
To assess the impact of H. pylori eradication on gastrin levels and gastric cell populations in AGCH patients.

Main Methods:

Comparative analysis of 12 AGCH patients and 8 H. pylori-positive duodenal ulcer patients.
Assessment of basal and peak acid outputs, gastrin-stimulation tests (meal and bombesin), and immunohistochemistry for antral G and D cells.

Related Experiment Videos

Re-evaluation of six AGCH patients one year after successful H. pylori eradication.

Main Results:

AGCH patients exhibited significantly higher basal and stimulated gastrin and acid secretion compared to H. pylori-positive duodenal ulcer patients.
AGCH patients showed significantly increased G cell counts and a higher G/D cell ratio.
H. pylori was present in all AGCH patients; eradication led to decreased gastrin levels, reduced G cell counts, and increased D cell counts.

Conclusions:

H. pylori overstimulation of gastrin cells, potentially in individuals with a genetic predisposition, may cause AGCH.
An imbalanced G/D cell ratio appears to play a role in the development of hypergastrinemia associated with AGCH.