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Related Experiment Videos

Urinary selenium excretion in infancy: comparison between term and preterm infants

H Tsukahara1, Y Deguchi, M Hiraoka

  • 1Department of Pediatrics, Fukui Medical School, Japan.

Biology of the Neonate
|January 1, 1996
PubMed
Summary

Urinary selenium (Se) levels peak at one month in term infants but decrease in preterm infants. Urinary Se reflects body stores, not renal function, serving as a marker for infant Se status.

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Area of Science:

  • Pediatric Nutrition
  • Trace Element Metabolism
  • Renal Physiology

Background:

  • Selenium (Se) is vital for glutathione peroxidase activity.
  • Understanding infant selenium status is crucial for development.
  • Urinary Se excretion is a potential noninvasive marker.

Purpose of the Study:

  • To evaluate urinary Se excretion in infants.
  • To examine the relationship between urinary Se and renal function.
  • To establish urinary Se as a marker for Se status in infants.

Main Methods:

  • Analyzed daytime spot urine samples from 80 infants (term and preterm) aged 1 week to 7 months.
  • Measured urinary Se concentration using fluorometry.
  • Assessed renal tubular function via beta 2-microglobulin levels using radioimmunoassay.

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Main Results:

  • Urinary Se peaked at 1 month in term infants.
  • Preterm infants showed higher urinary Se at 1 week but lower levels subsequently.
  • No significant correlation found between urinary Se and beta 2-microglobulin in any group.

Conclusions:

  • Renal Se excretion likely indicates body Se stores, independent of renal function in infants.
  • Urinary Se is a valuable, noninvasive tool for diagnosing and monitoring Se deficiency in infants.