An improved method for the detection of peptide-induced upregulation of HLA-A2 molecules on TAP-deficient T2 cells
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M Regner1, M H Claësson, S Bregenholt
1Department of Medical Anatomy, Panum Institute, University of Copenhagen, Denmark.
Experimental and Clinical Immunogenetics
|January 1, 1996
Abstract:
Peptide-induced upregulation of MHC class I on TAP-deficient T2 cells is used to monitor peptide binding to class I molecules. We present a temperature-dependent modification of the T2 assay which increases the sensitivity of peptide binding to MHC class I with several orders of magnitude.
