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Apo-E genotype and verbal deficits in Alzheimer's disease
D X Rasmusson1, G Dal Forno, J Brandt
1Department of Psychiatry/Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. xeno@mvx.grc.nia.nih.gov
The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1996
Abstract:
Apo-E genotype was not significantly related to cognitive performance in 157 Alzheimer's disease patients. However, patients homozygous for the epsilon 4 allele appeared most impaired on global cognition but least impaired on language measures. Further study with larger samples may reveal that Apo-E genotype accounts for some of the variability in cognitive deficits observed in Alzheimer's disease.