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Related Experiment Videos

[Transition of renal function after repeated intraperitoneal CDDP administration]

K Arai1, M Kitamura, Y Iwasaki

  • 1Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|September 1, 1996
PubMed
Summary

Intraperitoneal cisplatin (CDDP) after gastrectomy frequently caused renal dysfunction in outpatients. Current methods cannot easily or sensitively detect these kidney function changes, making the treatment not recommended.

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Area of Science:

  • Oncology
  • Nephrology
  • Gastroenterology

Context:

  • Post-gastrectomy cancer treatment
  • Intraperitoneal chemotherapy administration
  • Management of advanced gastric cancer

Purpose:

  • To evaluate the incidence and severity of renal dysfunction following intraperitoneal cisplatin (CDDP) administration in patients post-gastrectomy.
  • To assess the tolerability of this treatment regimen for outpatient settings.
  • To identify potential indicators of renal impairment during CDDP chemotherapy.

Summary:

  • This study monitored 20 patients receiving intraperitoneal CDDP post-gastrectomy, with doses ranging from 90-400 mg.
  • Renal dysfunction (up to grade 2) occurred in 35% of patients, and 12% of all administrations showed adverse renal events.

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  • Creatinine clearance declined with cumulative CDDP dose, but serum creatinine and BUN levels did not correlate, indicating a lack of sensitive biomarkers.

    • Impact:

    • Highlights the significant risk of renal dysfunction with intraperitoneal CDDP in post-gastrectomy patients.
    • Suggests that current clinical markers are insufficient for early detection of CDDP-induced nephrotoxicity in this setting.
    • Discourages the use of intraperitoneal CDDP for outpatients due to safety concerns and monitoring limitations.