[Study of hepatic arterial chemoinfusion with continuous CDDP, 5-FU low dose administration for advanced gallbladder...

Eight unresectable cases of gallbladder cancer underwent hepatic-artery infusion (HAI) with a consequent combination of cisplatin (CDDP) and 5-fluorouracil (5-FU) administration at a continuous low dose. Five cases (62.5%) showed a partial response (PR). Median survival time was 481.9 days. Cytoreductive surgery was performed in three patients of PR. One case has been disease free and alive over 52 months postoperatively. Gallbladder cancer is well known as a chemoresistant cancer, whereas the higher response rate and the longer survival were achieved with HAI. These results suggested CDDP, 5-FU HAI is a useful chemotherapy for advanced gallbladder cancer, and it is also worthwhile to introduce the preoperative down-staging for consequent cytoreduction surgery.