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Related Experiment Videos

Variable bile retention on cholescintigraphy after morphine administration

C K Kim1, J K Lim, J Machac

  • 1Mount Sinai School of Medicine, New York, NY 10029 USA.

European Journal of Nuclear Medicine
|November 1, 1996
PubMed
Summary
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Intravenous morphine sulfate did not significantly alter biliary kinetics in most patients undergoing cholescintigraphy for gallbladder nonvisualization. The drug

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Gastroenterology

Background:

  • Morphine sulfate is used with cholescintigraphy to evaluate gallbladder function.
  • Gallbladder nonvisualization is a common finding requiring further investigation.

Purpose of the Study:

  • To assess the effect of 2 mg intravenous morphine sulfate on biliary kinetics in patients with gallbladder nonvisualization.
  • To compare biliary kinetics with and without morphine administration.

Main Methods:

  • Cholescintigraphy was performed with and without morphine administration.
  • Time-activity curves (TACs) of the liver and common bile duct (CD) were analyzed.
  • Patients with gallbladder nonvisualization at 1 hour were studied.

Main Results:

Related Experiment Videos

  • 19 out of 24 morphine-augmented studies showed continued gallbladder nonvisualization.
  • Morphine administration resulted in increased CD activity in 9 patients and decreased activity in 8.
  • No significant effect of morphine on biliary kinetics was detected in a substantial proportion of patients.

Conclusions:

  • 2 mg intravenous morphine sulfate demonstrated no significant effect on biliary kinetics in many patients with gallbladder nonvisualization.
  • The duration of morphine's effect, when present, varied considerably.
  • These findings may impact the clinical use of morphine-augmented cholescintigraphy.