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Effect of postmenopausal estrogen replacement therapy on lipoproteins
1Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Safat.
Objectives:
To investigate the association between menopause and lipoproteins and the effect of hormone replacement therapy (HRT).
Methods:
Total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were estimated in 50 postmenopausal women and 25 ovulating women who served as controls. The lipoprotein estimations were repeated after 1 year of therapy with natural estrogen-norgestrel combination.
Results:
More postmenopausal women than younger women had lipoprotein values in the high-risk status (P <0.001). There were no significant changes in lipoprotein levels (P >0.05) after HRT. Women with a body mass index below 26 kg/m2 had a significant reduction in their lipoprotein risk status (P <0.01).
Conclusion:
There was no demonstrably clear effect of the estrogen-progestin combination on lipoprotein levels, probably because of other compounding variables such as obesity, lack of exercise and the type of progestin used.