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Related Experiment Videos

Elevated CA 125 in advanced abdominal or pelvic tuberculosis

S S Sheth1

  • 1Sheth Maternity and Gynaecological Nursing Home, Bombay, India.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|February 1, 1996
PubMed
Summary

Elevated CA 125 levels in women may indicate abdominopelvic tuberculosis, not just ovarian cancer. Early diagnosis through CA 125 testing can help avoid unnecessary surgery for this infection.

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Gynecology

Background:

  • Abdominopelvic tuberculosis can present with non-specific symptoms.
  • Ovarian malignancy is a common differential diagnosis for pelvic masses and ascites.
  • Cancer antigen 125 (CA 125) is a tumor marker often elevated in ovarian cancer.

Observation:

  • Three cases of advanced pelvic or abdominal tuberculosis presented with markedly elevated CA 125 levels.
  • This elevation mimicked findings typically associated with ovarian malignancy.
  • The patients' presentations included adnexal or abdominopelvic masses and/or ascites.

Findings:

  • Elevated CA 125 is not exclusive to ovarian malignancy.
  • Abdominopelvic tuberculosis can cause significant increases in CA 125.

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  • Diagnostic laparoscopy may be a valuable tool in differentiating tuberculosis from malignancy.

    • Implications:

    • Clinicians should consider abdominopelvic tuberculosis in the differential diagnosis for women with elevated CA 125, especially with masses or ascites.
    • Testing CA 125 in women with unexplained adnexal/abdominopelvic masses or ascites may aid in diagnosing tuberculosis.
    • This approach could help avoid invasive exploratory laparotomies when tuberculosis is the underlying cause.