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Analysis of serological surveys using mixture models: application to a survey of parvovirus B19
1Immunisation Division, PHLS Communicable Disease Surveillance Centre, London, U.K.
Statistics in Medicine
|July 30, 1996
Abstract:
A method for the analysis of age stratified antibody prevalence surveys is developed. The age specific distribution of the quantitative results of serological antibody tests is modelled as a mixture of seropositive and seronegative components. This yields maximum likelihood estimates of the prevalence at each age. The method is illustrated using data from a previously reported survey of antibody to parvovirus B19.