Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Venous valvular assessment after retrograde catheterization

J W Jaffe1, J A Newcomb, T York

  • 1Department of Radiology, Lehigh Valley Hospital, Allentown, PA 18105-1556, USA.

Journal of Vascular and Interventional Radiology : JVIR
|July 1, 1996
PubMed
Summary

Retrograde passage of infusion catheters through leg veins caused minimal valve damage in pigs. This suggests human venous valves may be safe during catheter-directed venous thrombolysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An antimicrobial evaluation of plants used for the treatment of respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa.

Journal of ethnopharmacology·2012
Same author

Plants used for treating respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa.

Journal of ethnopharmacology·2011
Same author

Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia.

Leukemia·2010
Same author

Evidence of a different dose response in turkeys when fed 2-hydroxy-4(methylthio) butanoic acid versus DL-methionine.

Poultry science·2007
Same author

Constraints on cosmological parameters from the analysis of the cosmic lens all sky survey radio-selected gravitational lens statistics.

Physical review letters·2002
Same author

Anastomotic fistula after ileal loop urinary diversion presenting as persistent urethral drainage.

The Journal of urology·2001

Area of Science:

  • Vascular Surgery
  • Interventional Radiology
  • Pathology

Background:

  • Venous access procedures are common in vascular interventions.
  • Catheter-directed venous thrombolysis aims to dissolve blood clots.
  • Potential for venous valve damage during retrograde catheterization is a concern.

Purpose of the Study:

  • To evaluate the safety of retrograde passage of a coaxial infusion system through valved extremity veins.
  • To determine the incidence and severity of venous valve damage.

Main Methods:

  • Retrograde common femoral vein puncture in anesthetized pigs.
  • Passage of an infusion wire-catheter system through superficial femoral and popliteal veins.
  • 8-hour infusion of heparinized saline followed by pathological examination of veins.

Related Experiment Videos

Main Results:

  • Minimal to no damage to venous valves was observed in most pigs.
  • Valvular damage occurred in only one of five pigs, potentially due to leg movement.
  • Control veins from the non-catheterized leg showed no damage.

Conclusions:

  • Retrograde passage of infusion systems appears safe for venous valves.
  • Findings suggest human venous valves may tolerate catheter-directed venous thrombolysis.
  • Further research is needed in deep venous thrombosis models.