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Lactase degradation by human enteric bacteria

V Bampoe, R J Sapsford, S Avigad

    Lancet (London, England)
    |July 21, 1979
    PubMed
    Summary
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    Microbes from children with diarrhea can break down non-human lactase enzyme. This microbial action may contribute to lactose intolerance by affecting human lactase activity.

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Enzymology

    Background:

    • Diarrhea in children can be linked to gut microbiome alterations.
    • Lactase enzyme is crucial for lactose digestion.
    • Understanding microbial impact on lactase is important for gastrointestinal health.

    Purpose of the Study:

    • To investigate the in vitro lactase-degrading potential of bacteria and yeast isolated from children with diarrhea.
    • To assess if these microbes could impact human lactase activity.

    Main Methods:

    • Isolation of bacterial and yeast strains from duodenal aspirates/mucosa of children with diarrhea.
    • In vitro testing of isolated strains for their ability to degrade non-human lactase.
    • Quantification of changes in lactase activity after microbial incubation.

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    Main Results:

    • Eleven bacterial strains and two yeast strains significantly reduced non-human lactase activity.
    • The tested microbes demonstrated a notable capacity for lactase degradation in vitro.

    Conclusions:

    • Microorganisms found in the duodenal environment of children with diarrhea possess lactase-degrading capabilities.
    • These microbial activities may play a role in the pathophysiology of lactose intolerance by affecting human lactase.