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Syngeneic tumor rejection induced by immunization with normal allogeneic tissues

R H Bear, O A Roholt, D Pressman

    Immunological Communications
    |January 1, 1977
    PubMed
    Summary

    Immunizing mice with normal allogeneic kidney and liver tissues improved survival against lymphoma. Combining tissues from multiple strains offered superior protection, suggesting shared tumor antigens.

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    Area of Science:

    • Immunology
    • Oncology
    • Transplantation Immunology

    Background:

    • Normal tissue immunization can impact tumor growth.
    • Tumor-associated transplantation antigens (TATA) play a role in immune responses to cancer.
    • Allogeneic tissues express non-H-2 alloantigens.

    Purpose of the Study:

    • To investigate the protective effect of normal allogeneic tissue immunization against syngeneic lymphoma.
    • To determine if combining tissues from multiple strains enhances protection.
    • To explore the role of tumor-associated transplantation antigens (TATA) in this phenomenon.

    Main Methods:

    • DBA/2Cr mice were immunized with normal allogeneic kidney and liver tissues.
    • Mice were subsequently challenged with a lethal dose of syngeneic L5178Y lymphoma cells.

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  • Survival rates were compared between groups immunized with single-strain tissues versus a combination of five strains.

    • Main Results:

    • Immunization with normal allogeneic kidney and liver tissues significantly extended the survival of mice challenged with L5178Y lymphoma.
    • Immunization using a combination of tissues from five different strains provided substantially greater protection compared to immunization with tissue from any single strain.
    • The findings suggest a cross-reactivity or identity between TATA on the L5178Y tumor and non-H-2 alloantigens present in the allogeneic tissues.

    Conclusions:

    • Normal allogeneic tissue immunization can confer protection against syngeneic lymphoma.
    • A multi-strain tissue immunization approach enhances anti-tumor protection.
    • The protective effect is likely mediated by shared antigens between the tumor and normal allogeneic tissues.