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Kinins in the cardiovascular system

B A Schölkens1

  • 1Hoechst Marion Roussel, Frankfurt am Main, Germany.

Immunopharmacology
|June 1, 1996
PubMed
Summary

The kallikrein-kinin-system (KKS) plays a vital role in cardiovascular regulation and protection. Modulating KKS pathways offers potential for innovative treatments for cardiovascular diseases.

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Area of Science:

  • Cardiovascular Physiology
  • Pharmacology

Background:

  • The kallikrein-kinin-system (KKS) components are present in cardiac and vascular tissues, forming local and systemic pathways.
  • Kinins, key mediators of KKS, influence cardiovascular regulation in health and disease via autocrine-paracrine mechanisms.

Purpose of the Study:

  • To explore the role of kinins and KKS modulation in endogenous cardio- and vasculoprotective mechanisms.
  • To investigate the interdependence of KKS and the Renin-Angiotensin-System (RAS) in cardiovascular function.

Main Methods:

  • Analysis of experimental models of hypertension, hypertrophy, ischemia, remodeling, and preconditioning.
  • Utilizing pharmacological tools like ACE inhibitors and kinin receptor antagonists.
  • Elucidation through molecular biology and clinical research.

Main Results:

  • Local KKS pathway modulation is crucial for endogenous cardio- and vasculoprotection.
  • Kinins exert beneficial cardiovascular effects, while receptor antagonism worsens outcomes.
  • ACE inhibitors highlight the complex interplay between KKS and RAS.

Conclusions:

  • Kinins are significant mediators of cardiovascular protective mechanisms.
  • Modulation of KKS pathways holds promise for innovative cardiovascular therapies.
  • Further research will clarify the molecular perception of kinins in cardiovascular health and disease.

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