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alpha-Tocopherylquinone: effect on blood pressure in normotensive volunteers and its plasma concentrations in men and
Abstract:
Three normotensive volunteers were given oral doses of alpha-tocopherylquinone. Blood pressure and its plasma concentrations were measured before and within 6 hours after taking this drug. Two dogs were given alpha-tocopherylquinone orally and after 3 days intravenously. Plasma concentrations were measured after each administration. Our result showed that this drug did not affect the blood pressure of normotensive individuals, and only small concentrations of alpha-tocopherylquinone were detected in plasma. In dogs, oral doses gave higher plasma levels than intravenous administration.
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