Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alzheimer's disease affects parallel processing between the auditory cortices

E Pekkonen1, M Huotilainen, J Virtanen

  • 1Department of Psychology, University of Helsinki, Finland.

Neuroreport
|May 31, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of EEG lead configuration on early TMS-EEG artifacts.

bioRxiv : the preprint server for biology·2026
Same author

Whole-brain computation of cognitive versus acoustic errors in music: A mismatch negativity study.

Neuroimage. Reports·2025
Same author

Identifying viral infections through analysis of head space volatile organic compounds.

Journal of breath research·2024
Same author

Double-blinded, randomised, placebo-controlled trial of convalescent plasma for COVID-19: analyses by neutralising antibodies homologous to recipients' variants.

Infectious diseases (London, England)·2024
Same author

Enhanced neural mechanisms of set shifting in musically trained adolescents and young adults: converging fMRI, EEG, and behavioral evidence.

Cerebral cortex (New York, N.Y. : 1991)·2023
Same author

Mechanisms behind the varying severity of Aleutian mink disease virus: Comparison of three farms with a different disease status.

Veterinary microbiology·2022
Same journal

Electroacupuncture alleviates neuroinflammation and promotes recovery of neurological functions after intracerebral hemorrhage by modulating α7nAChR/JAK2/STAT3 signaling pathway.

Neuroreport·2026
Same journal

Non-cell-autonomous regulation of Bhlhb5 expression in cortical projection neurons by GABAergic interneuron development and position.

Neuroreport·2026
Same journal

C-C motif chemokine ligand 3 mediates inflammatory response via NLRP3 inflammasome and neuron damage after traumatic brain injury.

Neuroreport·2026
Same journal

Methyltransferase-like 14 alleviates neuronal ferroptosis in Alzheimer's disease by regulating the peroxiredoxin 6/apoptosis signal-regulating kinase 1 signaling pathway.

Neuroreport·2026
Same journal

Hand mental rotation reaction time reflects motor imagery strategy and predicts changes in finger dexterity after motor imagery.

Neuroreport·2026
Same journal

Functional exploration of metabotropic glycine receptors in cultured rat hippocampal slices.

Neuroreport·2026
See all related articles

Alzheimer's disease (AD) patients show delayed auditory evoked magnetic fields (AEFs) in the ipsilateral auditory cortex. This suggests impaired parallel auditory processing, offering a potential biomarker for auditory dysfunction in AD.

Area of Science:

  • Neuroscience
  • Biomagnetism
  • Auditory Neuroscience

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
  • Auditory processing deficits are increasingly recognized in AD.
  • Objective biomarkers for early AD detection are needed.

Purpose of the Study:

  • To investigate auditory evoked magnetic fields (AEFs) in Alzheimer's disease (AD) patients.
  • To assess potential differences in auditory processing between AD patients and healthy controls.
  • To explore the utility of magnetoencephalography (MEG) as a diagnostic tool for AD-related auditory dysfunction.

Main Methods:

  • Magnetoencephalography (MEG) using a 122-channel whole-head magnetometer.
  • Recording auditory evoked magnetic fields (AEFs) in 11 AD patients and 11 age-matched controls.

Related Experiment Videos

  • Monaural auditory stimulation with varying interstimulus intervals (ISIs) of 0.5 s and 2.5 s.

    • Main Results:

    • Significantly longer peak latencies for P50m and N100m responses in AD patients compared to controls.
    • Latency differences were observed over the ipsilateral auditory cortex, but not the contralateral.
    • Findings suggest impaired parallel auditory processing between auditory cortices in AD.

    Conclusions:

    • Auditory evoked magnetic fields (AEFs) reveal significant processing delays in Alzheimer's disease (AD) patients.
    • The observed ipsilateral latency prolongation indicates impaired parallel auditory processing.
    • MEG measurements may serve as an objective index for evaluating auditory dysfunction in AD.