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Related Experiment Videos

Naloxone effects on sucrose-motivated behavior

J Cleary1, D T Weldon, E O'Hare

  • 1Department of Psychology, University of Minnesota, Minneapolis 55455, USA.

Psychopharmacology
|July 1, 1996
PubMed
Summary

The opioid antagonist naloxone reduces motivation to consume sugar solutions, especially at higher concentrations. This suggests naloxone

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pharmacology

Background:

  • The endogenous opioid system significantly influences feeding behaviors.
  • Opioid agonists generally stimulate feeding, while antagonists suppress it in non-food restricted animals.
  • Opioid antagonists are particularly effective at reducing sweet food consumption, though the mechanism is debated.

Purpose of the Study:

  • To investigate the effect of the opioid antagonist naloxone on motivation to obtain sucrose solutions of varying concentrations.
  • To compare naloxone's impact on motivated responding with its effect on consumption under conditions of unrestricted access.

Main Methods:

  • Utilized a progressive ratio (PR) reinforcement schedule to assess motivation for sucrose solutions.
  • Administered naloxone in a dose-dependent manner.
  • Measured sucrose solution consumption under conditions of unrestricted access.

Main Results:

  • Motivation to respond for sucrose increased with higher sucrose concentrations.
  • Naloxone dose-dependently decreased motivation to respond for sucrose.
  • Naloxone reduced consumption most significantly at higher sucrose concentrations under unrestricted access.

Conclusions:

  • Naloxone's effectiveness in reducing sweet food intake is indirectly related to the concentration of the food.
  • The findings suggest that naloxone's effects on sweet taste may be mediated by endogenous opioid reward pathways.
  • Motivation measures, assessed via PR schedules, reflect naloxone's impact on opioid-mediated reward systems.

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