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Receptors for gamma-interferon encoded by poxviruses: implications for the unknown origin of vaccinia virus
1Sir William Dunn School of Pathology, University of Oxford, UK. alcami@molbiol.ox.ac.uk
Trends in Microbiology
|August 1, 1996
Abstract:
Poxviruses encode soluble interferon-gamma receptors (IFN-gamma Rs) that inhibit IFN-gamma activity and play a major role in virus pathogenesis. In contrast to the highly species specific cellular homologues, the vaccinia IFN-gamma R has novel broad species specificity. This has implications for the unknown origin and natural host(s) of vaccinia virus, the vaccine used for smallpox eradication.