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Related Experiment Videos

Viral infection

M G Santoro1

  • 1Institute of Experimental Medicine, CNR, Rome, Italy.

EXS
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Viruses and cellular stress responses interact in complex ways, influencing viral replication. Stress proteins may play a role in controlling virus replication and development during infections.

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Area of Science:

  • Virology
  • Cellular Biology
  • Immunology

Background:

  • Viral infections significantly impact cellular stress responses in mammalian cells.
  • Interactions between stress proteins and viral components occur across various viral life cycle stages.
  • Heat shock proteins (HSPs) have been found within intact virions.

Purpose of the Study:

  • To explore the intricate relationship between viruses and the cellular stress response.
  • To discuss the potential role of stress proteins in regulating viral replication and morphogenesis.

Main Methods:

  • Review of existing literature on virus-stress response interactions.
  • Analysis of experimental models detailing stress protein involvement in viral infections.
  • Examination of the effects of induced stress responses on viral replication cycles.

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Main Results:

  • Viral infections frequently alter cellular stress responses.
  • Stress proteins interact with viral components throughout the infection process.
  • HSP expression modulation affects viral replication and can be influenced by hyperthermia.

Conclusions:

  • The interplay between viruses and cellular stress responses is complex and virus-dependent.
  • Stress proteins are implicated in controlling viral replication and morphogenesis.
  • Fever and hyperthermia's beneficial effects in acute infections may involve heat shock proteins.