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Premedication with intravenous antispasmodic speeds colonoscope insertion
1King Edward VII Memorial Hospital, Port Stanley, Falkland Islands.
Gastrointestinal Endoscopy
|March 1, 1996
Summary
Premedication with hyoscine n-butyl bromide before colonoscopy significantly reduced colonic spasm, making the procedure easier and quicker. This antispasmodic medication improved colonoscopy performance by easing scope insertion.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Antispasmodic medication use before colonoscopy is debated.
- Potential benefits include improved mucosal visualization and easier scope insertion.
Purpose of the Study:
- To evaluate the effect of hyoscine n-butyl bromide on colonoscopy performance.
- To assess its impact on colonic spasm, procedure difficulty, and patient comfort.
Main Methods:
- Prospective, double-blind, placebo-controlled trial.
- 56 patients received intravenous hyoscine or placebo with standard sedation.
- Assessed intubation/withdrawal times, colonic motility, and discomfort via visual analogue scales.
Main Results:
- Hyoscine group showed quicker intubation times (13 vs. 17.5 minutes, p=0.045).
- Significantly reduced colonic spasm in the hyoscine group (19 vs. 53.5 mm, p=0.01).
- Procedure perceived as significantly less difficult with hyoscine (p<0.05).
Conclusions:
- Intravenous hyoscine n-butyl bromide effectively reduces colonic spasm.
- This antispasmodic facilitates quicker and easier colonoscope insertion.
- Hyoscine premedication enhances overall colonoscopy performance.