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[Practical subjects of reference interval]

T Kanno1

  • 1Department of Laboratory Medicine, Hamamatsu University, School of Medicine, Japan.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 1, 1996
PubMed
Summary

This paper clarifies the determination and clinical laboratory use of reference intervals, building upon foundational concepts from the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the National Committee for Clinical Laboratory Standards (NCCLS). It ensures accurate interpretation of patient results.

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Area of Science:

  • Clinical Chemistry and Laboratory Medicine
  • Biostatistics and Reference Value Determination

Context:

  • The historical ambiguity of 'normal range' necessitated a more precise definition.
  • Key milestones include Dybkaer's 1973 proposal, IFCC's 1987 recommendations, and NCCLS's 1992 guidelines.
  • This work synthesizes these foundational concepts for practical application.

Purpose:

  • To describe and discuss methods for determining reference intervals.
  • To outline the utilization of reference intervals in clinical laboratory settings.
  • To provide a comprehensive overview based on IFCC and NCCLS frameworks.

Summary:

  • This paper details the evolution of the reference interval concept from its inception to current standards.
  • It elaborates on the methodologies for establishing reliable reference intervals.

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  • Practical guidance is provided on applying these intervals for accurate clinical interpretation.

    • Impact:

    • Enhances the precision and reliability of diagnostic testing in clinical laboratories.
    • Reduces misinterpretation of patient health status by standardizing reference value definitions.
    • Facilitates better clinical decision-making through the appropriate use of reference intervals.