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Exfoliation syndrome

Y J Lin1, T H Wang, S C Kao

  • 1Department of Opthalmology, National Taiwan University Hospital, Taipei.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|March 1, 1996
PubMed
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Exfoliation syndrome, a systemic condition, can first appear in the eyes, causing lens exfoliation and glaucoma. This case highlights its link with angle-closure glaucoma, managed effectively with surgery and medication.

Area of Science:

  • Ophthalmology
  • Genetics
  • Pathophysiology

Background:

  • Exfoliation syndrome is a systemic disorder characterized by abnormal basement membrane protein synthesis.
  • This protein accumulation can obstruct ocular structures, leading to conditions like glaucoma.
  • The eyes are often the initial site for manifestation of this systemic process.

Observation:

  • A 57-year-old male patient from Taiwan presented with exfoliation syndrome and angle-closure glaucoma.
  • The patient exhibited lens exfoliation and elevated intraocular pressure.
  • The underlying mechanism involved chronic angle-closure glaucoma exacerbated by exfoliation syndrome.

Findings:

  • Peripheral iridectomy and topical antiglaucoma medications were administered.
  • Intraocular pressure was successfully controlled between 15 to 20 mmHg in both eyes post-treatment.

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  • The glaucomatous optic neuropathy was attributed to the combined effects of exfoliation syndrome and angle-closure glaucoma.

    • Implications:

    • This case underscores the ocular manifestations of systemic exfoliation syndrome.
    • Effective management strategies exist for exfoliation syndrome-associated glaucoma.
    • Further research into the pathophysiologic link between exfoliation syndrome and glaucoma is warranted.