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Buflomedil poisoning: five cases with cardiotoxicity

A Legras1, R Piquemal, Y Furet

  • 1Medical Intensive Care Unit, Hopital Bretonneau, Tours, France.

Intensive Care Medicine
|January 1, 1996
PubMed
Summary

Buflomedil poisoning can cause severe cardiotoxicity, including seizures and cardiac arrest, in young women. Prompt medical intervention, including sodium bicarbonate, led to good recovery in all patients.

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Area of Science:

  • Toxicology
  • Cardiology
  • Pharmacology

Background:

  • Buflomedil is a medication with potential cardiotoxic effects.
  • Buflomedil poisoning can manifest with neurological and cardiac symptoms.

Observation:

  • Five young women presented with buflomedil poisoning, experiencing seizures and myoclonic jerks.
  • Two patients suffered cardiac arrest (asystole) shortly after ingestion.
  • Electrocardiogram findings included conduction abnormalities and prolonged QT interval.

Findings:

  • Buflomedil poisoning can induce direct cardiotoxicity, potentially due to sodium channel blockade.
  • Treatment with sodium bicarbonate showed improvement in electrocardiographic parameters.
  • All patients recovered without sequelae after intensive care.

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Implications:

  • Buflomedil's cardiotoxic potential necessitates careful monitoring in cases of poisoning.
  • Understanding the mechanism of toxicity may guide treatment strategies for buflomedil overdose.
  • This case series highlights the importance of recognizing and managing buflomedil-induced cardiotoxicity.