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Related Experiment Videos

Vitamin B-6 status indicators decrease in women consuming a diet high in pyridoxine glucoside

C M Hansen1, J E Leklem, L T Miller

  • 1Department of Nutrition and Food Management, Oregon State University, Corvallis 97331, USA.

The Journal of Nutrition
|October 1, 1996
PubMed
Summary
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The pyridoxine glucoside (PNG) form of vitamin B-6 reduces vitamin B-6 status indicators. Higher PNG intake in diets leads to decreased vitamin B-6 bioavailability, impacting overall status.

Area of Science:

  • Nutritional Biochemistry
  • Human Physiology
  • Dietary Assessment

Background:

  • Pyridoxine glucoside (PNG) is a common form of vitamin B-6.
  • Previous studies indicate PNG has lower bioavailability than pyridoxine.
  • The impact of PNG on vitamin B-6 status remains largely unassessed.

Purpose of the Study:

  • To evaluate the effect of dietary pyridoxine glucoside (PNG) on vitamin B-6 status in women.
  • To quantify the impact of varying PNG percentages on vitamin B-6 bioavailability.
  • To inform Recommended Dietary Allowances regarding PNG content in diets.

Main Methods:

  • A crossover study design involving nine women.
  • Consumption of diets with high (27%) and low (9%) PNG content for 18 days each, following an 8-day adjustment period.

Related Experiment Videos

  • Measurement of urinary and fecal vitamin B-6 excretion, plasma total vitamin B-6, and red blood cell pyridoxal 5'-phosphate (PLP).

    • Main Results:

    • Lower urinary 4-pyridoxic acid and total vitamin B-6 excretion during the high PNG diet period.
    • Significantly reduced plasma total vitamin B-6 and red blood cell PLP with higher PNG intake.
    • Increased fecal total vitamin B-6 excretion when consuming the high PNG diet, indicating reduced absorption.

    Conclusions:

    • A higher percentage of vitamin B-6 from PNG in the diet significantly decreases vitamin B-6 status indicators.
    • The reduced bioavailability of PNG results in an estimated 15-18% loss of total vitamin B-6 intake.
    • Dietary recommendations for vitamin B-6 should consider the bioavailability of PNG.