Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low-dose heparin thromboembolism prophylaxis

J T Owings1, F W Blaisdell

  • 1Department of Surgery, University of California, Davis, Medical Center, Sacramento, USA.

Archives of Surgery (Chicago, Ill. : 1960)
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a new automated quantitative d-dimer, Advanced D-Dimer, in patients suspected of venous thromboembolism.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2002
Same author

Platelet activation and function after trauma.

The Journal of trauma·2001
Same author

Biochemical basis for the hypercoagulable state seen in Cushing syndrome; discussion 1006-7.

Archives of surgery (Chicago, Ill. : 1960)·2001
Same author

Practical utility of the D-dimer assay for excluding thromboembolism in severely injured trauma patients.

The Journal of trauma·2001
Same author

Systemic coagulation and fibrinolysis after laparoscopic and open gastric bypass.

Archives of surgery (Chicago, Ill. : 1960)·2001
Same author

Vascular surgeon Edwin J. Wylie, MD (1918-1982), pioneer and visionary.

Vascular surgery·2001

Adjusted-dose heparin is the safest and most reliable method for preventing blood clots (thromboembolism). This approach ensures optimal prophylaxis compared to standard low-dose or low-molecular-weight heparin regimens.

Area of Science:

  • Medical Science
  • Pharmacology

Background:

  • Thromboembolism prophylaxis is crucial in preventing serious medical complications.
  • Heparin is a widely used anticoagulant for this purpose.
  • Optimal dosing strategies are essential for efficacy and safety.

Purpose of the Study:

  • To identify the most rational and effective heparin dosing strategy for preventing thromboembolism.
  • To compare different heparin regimens for their safety and reliability.

Main Methods:

  • A comprehensive literature review was conducted.
  • Commonly used heparin dosing regimens were identified and analyzed.

Main Results:

  • Three primary regimens were identified: standard low-dose heparin, adjusted-dose heparin, and low-molecular-weight heparin.

Related Experiment Videos

  • Standard low-dose heparin involves 5000 U subcutaneously 2-3 times daily.
  • Adjusted-dose heparin aims to prolong activated partial thromboplastin time (aPTTT) by 5 seconds above normal, while low-molecular-weight heparin is administered as 30 mg subcutaneously twice daily without monitoring.

    • Conclusions:

    • Adjusted-dose heparin demonstrates superior safety and reliability for thromboembolism prophylaxis.
    • This method offers a rational approach to heparin therapy, optimizing patient outcomes.