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Apolipoprotein E in neurology

A D Roses1

  • 1Alzheimer's Disease Research Center, Department of Medicine (Neurology), Duke University Medical Center, Durham, North Carolina 27110-2900, USA.

Current Opinion in Neurology
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

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Apolipoprotein E (ApoE) epsilon 4 allele is linked to Alzheimer disease. Research is expanding on ApoE's role in central nervous system metabolism.

Area of Science:

  • Neurobiology
  • Genetics
  • Neurology

Background:

  • Apolipoprotein E (ApoE) gained significance in neurology in 1993.
  • The ApoE-epsilon 4 allele was associated with Alzheimer disease (AD).
  • Numerous studies have since confirmed this association.

Purpose of the Study:

  • To review the growing body of literature on Apolipoprotein E.
  • To highlight the established link between ApoE and Alzheimer disease.
  • To discuss the developing understanding of ApoE's function in the central nervous system.

Main Methods:

  • Literature review of research papers.
  • Analysis of studies confirming the ApoE-epsilon 4 association with AD.
  • Synthesis of neurobiological findings.

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Main Results:

  • The association of the ApoE-epsilon 4 allele with late-onset Alzheimer disease is well-established.
  • Over 100 studies have confirmed the link between ApoE-epsilon 4 and Alzheimer disease.
  • A significant body of neurobiological research now exists.

Conclusions:

  • Apolipoprotein E is a critical factor in Alzheimer disease pathogenesis.
  • Ongoing research is elucidating the role of ApoE in central nervous system metabolism.
  • The ApoE-epsilon 4 allele remains a key genetic risk factor for Alzheimer disease.