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Polyneuropathy in impotence

Y Vardi1, E Sprecher, Y Kanter

  • 1Department of Urology, Rambam Medical Center, Haifa, Israel.

International Journal of Impotence Research
|June 1, 1996
PubMed
Summary
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Polyneuropathy (PNP) is common in impotent men, affecting 19% overall. This nerve condition is prevalent in diabetics and may contribute to erectile dysfunction, with nocturnal penile tumescence tests effectively identifying organic causes.

Area of Science:

  • Neurology
  • Urology
  • Endocrinology

Background:

  • Erectile dysfunction (ED) is a common condition with multifactorial causes.
  • Polyneuropathy (PNP) is a potential contributor to ED, particularly in diabetic patients.
  • Distinguishing between neurogenic and vasculogenic causes of ED is crucial for effective treatment.

Purpose of the Study:

  • To evaluate the prevalence of polyneuropathy (PNP) in impotent patients.
  • To assess the utility of neurophysiological and psychophysical tools in diagnosing PNP in this population.
  • To determine if specific diagnostic tests can differentiate the causes of impotence.

Main Methods:

  • Neurophysiological and psychophysical assessments, including nerve conduction studies and quantitative sensory testing (thermal and vibratory).

Related Experiment Videos

  • Evaluation of 341 consecutive impotent patients.
  • Utilized nocturnal penile tumescence (NPT) testing and vasoactive drug injection tests.

    • Main Results:

    • Overall, 19% of impotent patients exhibited polyneuropathy (PNP).
    • PNP prevalence was higher in diabetics (38%) compared to non-diabetics (10%).
    • No significant difference in PNP rates was observed between 'neurogenic' (21%) and 'vasculogenic' (23%) impotence, suggesting vasoactive drug injection tests are not discriminatory.

    Conclusions:

    • Polyneuropathy (PNP) is a common finding in impotent patients and may play a causative role.
    • Vasoactive drug injection tests are not effective in differentiating neurogenic from non-neurogenic impotence.
    • Nocturnal penile tumescence (NPT) testing reliably distinguishes psychogenic from organic impotence, especially when PNP is a factor, as patients with normal NPT showed very low rates of PNP.