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Intraoperative mitomycin-C versus postoperative topical mitomycin-C drops for the treatment of pterygium
1Department of Ophthalmology, El-Maghraby Eye Center, Jeddah, Saudi Arabia.
Background And Objective:
To evaluate the safety and efficacy of two different regimens of mitomycin-C (MMC) application as adjunctive chemotherapy in the treatment of pterygia.
Patients And Methods:
One hundred fifty-six patients underwent pterygium excision using the bare sclera technique. They were randomly assigned to have either 0.1 mg/ml of MMC applied to the bare sclera for 3 minutes intraoperatively, or 0.05-mg/ml drops applied topically for 2 weeks postoperatively. The mean follow-up period was 11 months (range 7 to 17).
Results:
Complications with the intraoperative MMC included 5 cases of recurrence (5.75%), 2 cases of superficial punctate keratitis (SPK), and 3 cases of delayed conjunctival wound healing. Topical MMC led to 6 cases of recurrence (6.9%), 5 cases of SPK, 4 cases of delayed conjunctival wound healing, and 2 cases of mild iritis.
Conclusion:
A single, intraoperative application of MMC is a simple, effective alternative adjunctive treatment for pterygium.