Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A pencil beam algorithm for proton dose calculations

L Hong1, M Goitein, M Bucciolini

  • 1Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA.

Physics in Medicine and Biology
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of risk factors for acute kidney injury following reoperative cardiac surgery].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

[Expert consensus on the clinical application of endometrial ablation].

Zhonghua fu chan ke za zhi·2025
Same author

Haematotoxicity of Craniospinal Radiochemotherapy for Metastatic Paediatric High-Grade Glioma.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

[Analysis of factors associated with false-positive results and optimal positivity thresholds of quantitative fecal immunochemical test in colorectal cancer screening].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

[The practice and exploration on the continuous medical service in children's hospital].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

[Whole-process, sequential and proactive nutritional management strategies for cow's milk protein allergy in infants and young children].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026
Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026
Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026
Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
See all related articles

A new proton dose calculation algorithm accurately models upstream materials and air gaps, improving proton radiation therapy precision. This enhances the sharp penumbra and dose fall-off, crucial for effective cancer treatment.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Dosimetry

Background:

  • Proton therapy offers superior dose conformity due to sharp lateral penumbra and rapid dose fall-off.
  • Accurate modeling of beam-modifying devices and air gaps is critical for realizing these benefits.
  • Existing algorithms may not fully account for upstream material and air gap effects.

Purpose of the Study:

  • To develop and validate a novel pencil beam algorithm for proton dose calculations.
  • To accurately incorporate the influence of upstream beam modifiers and air gaps.
  • To improve the modeling of proton beam penumbra and dose distribution.

Main Methods:

  • Developed a pencil beam algorithm incorporating upstream materials and air gap effects.

Related Experiment Videos

  • Introduced a new method for selecting pencil beam locations to improve penumbra modeling.
  • Created a faster broad-beam version of the algorithm for practical applications.
  • Validated the algorithm using experimental data from a large-field proton beam.

    • Main Results:

    • The algorithm accurately accounts for upstream materials and air gaps in proton dose calculations.
    • The new pencil beam placement strategy improves penumbra accuracy.
    • Experimental validation showed good agreement between the algorithm's predictions and measured data.
    • The broad-beam version provides reasonably accurate penumbra calculations.

    Conclusions:

    • The developed algorithm enhances the accuracy of proton dose calculations, particularly concerning upstream effects.
    • This improved modeling can lead to more precise radiation delivery in proton therapy.
    • The findings support the use of this algorithm for optimizing treatment planning and delivery.