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Serum trypsinogen-2 in the prediction of outcome in acute necrotizing pancreatitis
V Sainio1, P Puolakkainen, E Kemppainen
1Dept. II of Surgery, Helsinki University Central Hospital, Finland.
Background:
The accuracy of serum trypsinogen-2 in predicting the severity of acute necrotizing pancreatitis (ANP) was prospectively evaluated in 52 consecutive patients.
Methods:
A new sensitive immunofluorometric assay was used for serum trypsinogen-2,
Results:
Mean values during the first 24 h were 42.1 micrograms/l in control patients, 1435 micrograms/l in uncomplicated cases, and 4090 micrograms/l in complicated or fatal cases. There was a significant difference in serum trypsinogen-2 values between patients with uncomplicated and complicated disease (p = 0.002) already on admission. When a cutoff level of 1000 micrograms/l was used, patients with uncomplicated ANP were differentiated from patients with complicated ANP with a sensitivity of 91% and with a specificity of 71%.
Conclusions:
The immunofluorometric assay of serum trypsinogen-2 is a sensitive and specific method for prediction of the severity of the disease in necrotizing pancreatitis.
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Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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Acute Pancreatitis II: Clinical Manifestations and Management
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Assessment:
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Chronic Pancreatitis II: Pathophysiology