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Neonatal presentation of Gordon syndrome
J E Gereda1, M Bonilla-Felix, B Kalil
1Department of Pediatrics, University of Texas-Houston Health Science Center 77030, USA.
Insights
Gordon syndrome, characterized by hypertension and hyperkalemic acidosis, was identified in infants. Early diagnosis and treatment with thiazides proved effective in these youngest documented cases, offering new insights into pediatric management.
Area of Science:
- Pediatric Nephrology
- Endocrinology
- Genetics
Background:
- Gordon syndrome, a rare condition linking hypertension and hyperkalemic acidosis, is typically diagnosed in older children and adults.
- The early-onset presentation and metabolic derangements in infancy remain under-documented.
Abstract:
Gordon syndrome, the association of hypertension with hyperkalemic acidosis, has been described in older children and adults. We report an affected family in which two of the members had exhibited the metabolic manifestations of the disease since infancy. Both patients responded well to thiazides. To our knowledge, these are the youngest patients with documented cases of Gordon syndrome.