In vitro release of new quinolones from biodegradable systems: a comparative study
Related Experiment Video
Updated: Nov 4, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
A G Andreopoulos1, T Korakis, E Dounis
1Department of Chemical Engineering, National Technical University of Athens, Zografou Athens, Greece.
Abstract:
A new biodegradable delivery system based on low molecular weight poly(lactic acid) has been formulated, with potential application in the sustained antibiotic release against bone infection. The in vitro release of two new quinolones (ofloxacin and ciprofloxacin) from the biodegradable matrix showed that the delivery of ofloxacin from the matrix lasted fifty-six days, whereas that of ciprofloxacin lasted fifty-one days. In both cases, release is controlled by the drug diffusion and the matrix degradation, the latter being the most critical factor. The obtained concentration levels are well above the Minimum Inhibitory Concentration (MIC) against the major causative bacteria of osteomyelitis. This fact in combination with the good reproducibility of measurements indicated that the system studied could be of value for the preparation of implantable controlled release systems for treatment of diseases in the bone system.
More Related Videos
Related Concept Videos
Modified-Release Drug Delivery Systems: Bioavailability
In Vitro Drug Release Testing: Overview, Development and Validation
In Vitro Drug Dissolution: Alternative Methods
In Vitro Drug Dissolution: Compendial Testing Models I
Inhibitors of Bacterial DNA Synthesis
In Vitro Drug Dissolution: Compendial Testing Models II

