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Related Experiment Videos

Hydroxyproline excretion in infantile gastroenteritis

R H Begent, H P Lambert

    Journal of Clinical Pathology
    |July 1, 1977
    PubMed
    Summary
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    The total hydroxyproline/creatinine ratio (THP:Cr) in infants with gastroenteritis may indicate illness severity. Low THP:Cr levels suggest potential failure to thrive, aiding in early patient management.

    Area of Science:

    • Biochemistry
    • Pediatrics
    • Clinical Nutrition

    Background:

    • Gastroenteritis in infants can lead to nutritional challenges and failure to thrive.
    • Assessing metabolic changes during illness is crucial for effective pediatric care.
    • The total hydroxyproline/creatinine ratio (THP:Cr) reflects collagen turnover, a potential marker for metabolic status.

    Purpose of the Study:

    • To investigate the utility of the total hydroxyproline/creatinine ratio (THP:Cr) in infants diagnosed with gastroenteritis.
    • To determine if THP:Cr levels correlate with the acute phase of gastroenteritis or subsequent failure to thrive.

    Main Methods:

    • Measurement of the total hydroxyproline/creatinine ratio (THP:Cr) in random urine samples.
    • Analysis of THP:Cr levels in 18 infants during the acute phase of gastroenteritis.

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  • Correlation of THP:Cr levels with clinical outcomes, specifically failure to thrive.

    • Main Results:

    • The THP:Cr ratio showed variability during the acute phase of gastroenteritis.
    • Seven infants who subsequently failed to thrive exhibited low THP:Cr levels.
    • Elevated THP:Cr was observed in some infants during the acute illness phase.

    Conclusions:

    • The total hydroxyproline/creatinine ratio (THP:Cr) may serve as a sensitive indicator for the early detection of failure to thrive in infants post-gastroenteritis.
    • Monitoring THP:Cr could be valuable for managing infants at risk of poor growth following acute illness.
    • Further research is warranted to elucidate the specific mechanisms behind THP:Cr fluctuations in pediatric gastroenteritis.