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Neurotoxicity Assessment in Adult Danio rerio using a Battery of Behavioral Tests in a Single Tank
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Animal behavioral methods in neurotoxicity assessment: SGOMSEC joint report

B Kulig1, E Alleva, G Bignami

  • 1TNO Nutrition and Food Research Institute, Utrechtsweg, The Netherlands.

Environmental Health Perspectives
|April 1, 1996
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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