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Deformation kinetics analysis of polymeric matrices

S K Lum1, W C Duncan-Hewitt

  • 1Faculty of Pharmacy, University of Toronto, Ontario, Canada.

Pharmaceutical Research
|May 1, 1996
PubMed
Summary

Understanding tablet compression kinetics, this study quantifies deformation parameters like activation volume (Vact) and activation energy (Eact) in poly(methyl methacrylate-co-methacrylic acid) (PMMA/coMAA) for improved production control.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Technology

Background:

  • Tablet compression is crucial in pharmaceutical manufacturing.
  • Understanding polymer deformation kinetics is key to controlling tablet properties.
  • Poly(methyl methacrylate-co-methacrylic acid) (PMMA/coMAA) serves as a model viscoelastic polymer.

Purpose of the Study:

  • To quantify deformation kinetic parameters: activation volume (Vact) and activation energy (Eact).
  • To investigate the predominant barrier to deformation in PMMA/coMAA.
  • To provide data for a time-dependent particle deformation model.

Main Methods:

  • Performed stress relaxation studies at varying temperatures using an instrumented Instron testing apparatus.
  • Quantified shear stress rates via solid density, microindentation hardness, and contact area testing.
  • Applied different strain rates (1, 2, and 5 mm/min) during experiments.

Main Results:

  • Activation volume (Vact) values ranged from 63.8 to 79.1 b(3) across tested strain rates.
  • Activation energy (Eact) for flow increased with strain rate, from 145 kJ/mole(-1) to 506 kJ/mole(-1).
  • Results indicate strain hardening effects influencing polymer deformation.

Conclusions:

  • The determined activation volumes and energies are essential for modeling tablet compaction.
  • These parameters provide insights into the viscoelastic behavior of PMMA/coMAA during compression.
  • The findings contribute to better control over tablet production parameters.

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