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Solvent and plasticizer influences on ethylcellulose-microcapsules

M E Palomo1, M P Ballesteros, P Frutos

  • 1Departmento de Farmacia y Tecnologia Farmaceutica, Universidad Complutense de Madrid, Madrid, Spain.

Journal of Microencapsulation
|May 1, 1996
PubMed
Summary

This study explores how different solvents affect ethylcellulose microcapsule formation for diclofenac sodium. Solvent choice significantly impacts microcapsule properties, influencing drug delivery potential.

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Chemical Engineering

Background:

  • Microencapsulation processes lack standardized protocols, leading to unpredictable product outcomes.
  • Variations in parameters like temperature, stirring, and solvent type significantly alter microcapsule characteristics.
  • Ethylcellulose (EC) microcapsules are investigated for encapsulating diclofenac sodium (DFNa), an anti-inflammatory drug sensitive to gastric conditions.

Purpose of the Study:

  • To investigate the influence of different solvents on ethylcellulose microcapsule formation.
  • To evaluate the impact of ethylphthalate as a plasticizer on drug release kinetics.
  • To optimize microencapsulation techniques for controlled drug delivery.

Main Methods:

  • Ethylcellulose microcapsules were prepared using four solvents: ethanol (aqueous), acetone, chloroform, and toluene (organic).

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  • Diclofenac sodium was encapsulated as the model drug.
  • Ethylphthalate was incorporated into selected microcapsules to assess its effect on film permeability and drug release.

    • Main Results:

    • The choice of solvent significantly influenced the formation and properties of ethylcellulose microcapsules.
    • Organic solvents resulted in different microcapsule characteristics compared to the aqueous solvent.
    • The addition of ethylphthalate modified film permeability, affecting the drug release rate.

    Conclusions:

    • Solvent selection is a critical factor in controlling ethylcellulose microcapsule properties.
    • Microencapsulation parameters, including solvent choice and plasticizer addition, can be tailored for specific drug delivery applications.
    • Further research into solvent effects can lead to more predictable and efficient microencapsulation processes.