Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pure red-cell aplasia: a review

A J Erslev1, A Soltan

  • 1Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Blood Reviews
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erythropoietin and anemia of cancer.

European journal of haematology·2000
Same author

Induction of ovulation in women undergoing assisted reproductive techniques: recombinant human FSH (follitropin alpha) versus highly purified urinary FSH (urofollitropin HP).

Human reproduction (Oxford, England)·2000
Same author

Platelet kinetics in autosomal dominant macrothrombocytopenia.

The Journal of laboratory and clinical medicine·1998
Same author

Immunochemical purification and characterization of a 74.0-kDa Schistosoma mansoni antigen.

The Journal of parasitology·1998
Same author

Clinical erythrokinetics: a critical review.

Blood reviews·1997
Same author

Does lymph node dissection still have a role in cancer therapy?

Seminars in oncology·1997
Same journal

Treating large B-cell lymphoma: Current strategies and unmet needs across community and academic settings.

Blood reviews·2026
Same journal

MRD in multiple myeloma: Moving from "minimal" to "measurable".

Blood reviews·2026
Same journal

PRISMA-based systematic review on iron stores in repeat blood donors.

Blood reviews·2026
Same journal

Artificial intelligence applications in thrombotic thrombocytopenic Purpura: A systematic review of diagnostic, risk stratification, and prognostic models.

Blood reviews·2026
Same journal

Antibacterial, antifungal and antiviral prophylaxis and vaccination strategies in adult patients with acute myeloid and promyelocytic leukemia: An expert panel consensus from the GIMEMA group.

Blood reviews·2026
Same journal

The Lebanese national patient blood management guidelines: A new page in the medical practice.

Blood reviews·2026
See all related articles

Pure red-cell aplasia, an anemia with absent red blood cells, can be congenital or acquired. Acquired cases are often linked to B19 parvovirus or lymphoid diseases, with treatments like corticosteroids showing promise.

Area of Science:

  • Hematology
  • Immunology
  • Virology

Background:

  • Pure red-cell aplasia (PRCA) is a rare anemia defined by the near absence of nucleated red blood cells.
  • It presents in congenital and acquired forms, with distinct underlying mechanisms.
  • Acquired PRCA is frequently associated with specific viral infections or lymphoid disorders.

Purpose of the Study:

  • To elucidate the causes and characteristics of pure red-cell aplasia.
  • To understand the etiological factors contributing to both congenital and acquired forms of PRCA.
  • To review the clinical course and treatment outcomes for patients with PRCA.

Main Methods:

  • Review of existing literature on pure red-cell aplasia.
  • Analysis of etiological factors including viral agents (e.g., B19 parvovirus) and underlying diseases.

Related Experiment Videos

  • Examination of treatment modalities and their efficacy, particularly immunosuppressive therapy.

    • Main Results:

    • Congenital PRCA may result from intrauterine damage to erythroid stem cells.
    • Transient acquired PRCA is often caused by B19 parvovirus infection.
    • Sustained acquired PRCA is linked to viral infections, immune responses, or toxic damage, frequently in patients with lymphoid diseases.

    Conclusions:

    • Pure red-cell aplasia has diverse etiologies, ranging from congenital defects to acquired triggers like parvovirus and lymphoid malignancies.
    • Treatment with immunosuppressive drugs, especially corticosteroids, can induce remission in many cases.
    • Patient outcomes are largely dependent on the management of the primary underlying disorder.