Quinolone prophylaxis in transurethral surgery

In transurethral surgery, there is much controversy about the benefit of antimicrobial prophylaxis. Any urinary tract infection should be treated before proceeding with a transurethral operation. There is growing evidence that antimicrobial prophylaxis is also beneficial in cases with preoperatively sterile urine. A single dose or short-term prophylaxis appears to be sufficient. As newer fluoroquinolones reach very high tissue concentrations, have a suitable antimicrobial spectrum to cover most uropathogens and can be administered orally, these new drugs represent an attractive choice for prophylaxis in transurethral surgery.