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Pharmacotherapy of opioids: present and future developments
1Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
Pharmacy World & Science : PWS
|January 1, 1996
Summary
Opioid medications have varied properties but similar side effects. Strategies like alternative administration routes, optimized delivery, and adjuvant analgesics can mitigate these adverse effects during perioperative care.
Area of Science:
- Pharmacology
- Anesthesiology
- Pain Management
Background:
- Clinically available opioids exhibit diverse physicochemical properties influencing potency, onset, and duration.
- Despite differing profiles, opioids share comparable side-effect profiles after acute systemic administration.
Purpose of the Study:
- To review strategies for overcoming opioid-related side effects, particularly in the perioperative setting.
- To explore novel analgesic development based on pain pathway and opioid receptor knowledge.
Main Methods:
- Discussion of alternative administration routes (epidural, intrathecal).
- Review of optimized opioid delivery systems (slow-release, infusions, transdermal).
- Examination of adjuvant analgesics and novel analgesic discovery.
Main Results:
- Alternative routes and optimized delivery can manage opioid side effects.
- Adjuvant agents can reduce required opioid dosage.
- Understanding pain pathways aids new analgesic development.
Conclusions:
- Multiple strategies exist to manage opioid side effects in perioperative pain management.
- Future research focuses on targeted analgesics with improved safety profiles.