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Perforated colorectal carcinomas

N Mandava1, S Kumar, W F Pizzi

  • 1Department of Surgery and Oncology, Catholic Medical Center of Brooklyn & Queens, Inc, Mary Immaculate Hospital, Jamaica, USA.

American Journal of Surgery
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

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Perforated colorectal carcinomas (PCCs) may not have a poor prognosis. Aggressive management, including sepsis control and radical surgery, can lead to a 58% survival rate in select patients.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Colorectal carcinoma with perforation historically carries a poor prognosis.
  • This study aimed to evaluate the prognosis of perforated colorectal carcinomas (PCCs).

Purpose of the Study:

  • To verify or refute the negative prognosis associated with perforated colorectal carcinomas.
  • To assess survival rates and outcomes for patients with PCCs.

Main Methods:

  • Retrospective analysis of 1551 colorectal carcinoma patients from 1983-1993.
  • Identified 51 patients (3.3%) presenting with perforation.
  • Reviewed patient charts and tumor board data.

Main Results:

  • Localized perforation with abscess in 61% of patients; free perforation in 39%.

Related Experiment Videos

  • 16 patients (31%) had distant metastasis at diagnosis with a 6-month mean survival.
  • Excluding Stage IV disease and operative mortalities, 32 patients showed a 58% 5-year survival rate.

    • Conclusions:

    • Aggressive management, including sepsis control and radical surgery, is recommended for PCCs.
    • A negative outlook for PCCs is not supported by this 10-year retrospective study.
    • The study suggests improved survival outcomes with appropriate interventions.