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Neither physical exercise nor alpha 1- and beta-adrenergic blockade affect plasma endothelin concentrations
A Cosenzi1, A Sacerdote, E Bocin
1Istituto di Medicina Clinica, University of Trieste, Italy.
American Journal of Hypertension
|August 1, 1996
Summary
Prolonged aerobic exercise does not alter plasma endothelin (ET) levels in healthy young adults. Furthermore, alpha- and beta-blockade did not impact ET concentrations at rest or during exercise.
Area of Science:
- Cardiovascular Physiology
- Endocrinology
Background:
- Endothelins (ET) are potent vasoconstrictors released by endothelial cells.
- Factors influencing ET release may be modulated by prolonged exercise.
Purpose of the Study:
- To examine the impact of physical exercise on plasma ET concentrations.
- To assess the effect of alpha- and beta-adrenoceptor blockade on ET levels at rest and during exercise.
Main Methods:
- Fifteen healthy young volunteers underwent graded bicycle ergometer exercise.
- Blood samples were collected pre- and post-exercise.
- The protocol was repeated after administration of carvedilol (an alpha- and beta-blocker).
Main Results:
- Plasma ET concentrations did not significantly change after prolonged aerobic exercise.
- Alpha- and beta-adrenoceptor blockade did not affect ET levels at rest or post-exercise.
- No significant differences in ET levels were observed with or without carvedilol administration.
Conclusions:
- Prolonged aerobic exercise does not appear to influence plasma ET levels in healthy young individuals.
- Alpha- and beta-adrenoceptor blockade does not alter ET concentrations in this population, either at rest or during exercise.