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Related Experiment Videos

Lag phase quantification for solid gastric emptying studies

H A Ziessman1, F B Atkins, U S Vemulakonda

  • 1Department of Radiology, Georgetown University Hospital, Washington, D.C. 20007, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|October 1, 1996
PubMed
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The modified power exponential (MPE) method for calculating gastric emptying lag phase showed poor correlation with other methods. Its accuracy is affected by temporal sampling rates, unlike the transition point, starting index, and first appearance of bowel activity (FABA).

Area of Science:

  • Nuclear medicine
  • Gastroenterology
  • Pharmacokinetics

Background:

  • Gastric emptying lag phase is a crucial parameter in assessing gastrointestinal motility.
  • Various methods exist for calculating the gastric emptying lag phase, but their comparability and reliability are not fully established.
  • The modified power exponential (MPE) method is one such technique, but its accuracy may be influenced by data acquisition parameters.

Purpose of the Study:

  • To compare different calculation methods for the solid gastric emptying lag phase.
  • To evaluate the impact of temporal sampling intervals on lag phase calculations using the MPE method.

Main Methods:

  • Utilized gamma camera imaging with frame-by-frame acquisition (1 min intervals) in 20 healthy subjects and 42 patients.

Related Experiment Videos

  • Generated time-activity curves (TACs) for stomach, antrum, and small bowel.
  • Calculated lag phase using transition point, starting index, first appearance of bowel activity (FABA), MPE, and antral peak filling time.
  • Analyzed MPE method's sensitivity to temporal sampling intervals ranging from 1 to 20 minutes.

    • Main Results:

    • Transition point, starting index, and FABA showed high correlation (r ≥ 0.92) and similar normal lag phase values (mean 22-24 min).
    • The MPE method yielded significantly longer lag phase values (mean 47 min) and correlated poorly with the other methods (r = 0.74).
    • A 15-minute sampling interval, compared to 1-minute, resulted in >7.5 min differences in MPE calculations for 35% of subjects and >15 min for 10%.

    Conclusions:

    • The MPE method for gastric emptying lag phase calculation demonstrates poor correlation with established methods like transition point, starting index, and FABA.
    • The accuracy of the MPE method is significantly limited by the temporal sampling rate.
    • Transition point, starting index, and FABA are reliable indicators, with FABA being particularly robust and easily quantifiable from small bowel TACs.