Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteins in unexpected locations

N R Smalheiser1

  • 1Department of Pediatrics, University of Chicago, Illinois 60637, USA.

Molecular Biology of the Cell
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Many proteins function outside their usual cellular locations, sometimes with unique roles and regulation. This finding impacts our understanding of cell organization and diseases like cancer and Alzheimer's.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiology.

Translational psychiatry·2015
Same author

RNAi and brain function: was McConnell on the right track?

Trends in neurosciences·2001
Same author

Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro.

European journal of pharmacology·2001
Same author

Coordinate enrichment of cranin (dystroglycan) subunits in synaptic membranes of sheep brain.

Brain research·2001
Same author

Walter Pitts.

Perspectives in biology and medicine·2000
Same author

Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells.

Proceedings of the National Academy of Sciences of the United States of America·2000

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Proteins are traditionally understood to perform specific functions within defined cellular compartments.
  • However, accumulating evidence suggests proteins can exist and act in non-canonical locations.

Purpose of the Study:

  • To explore the phenomenon of proteins functioning in multiple cellular compartments.
  • To investigate the implications of this multi-compartmental protein activity for cell biology and disease.

Main Methods:

  • Literature review and synthesis of existing research findings.
  • Analysis of studies identifying proteins in non-conventional cellular locations.
  • Examination of protein isoforms, translocation mechanisms, and compartment-specific regulation.

Related Experiment Videos

Main Results:

  • Proteins from all major classes (e.g., cytoskeletal, secreted, enzymes, transcription factors) have been found in unexpected cellular compartments.
  • Some proteins exhibit compartment-specific isoforms and distinct biological actions in different locations.
  • Novel mechanisms for intercompartmental protein movement and compartment-specific regulation have been identified.

Conclusions:

  • Proteins may possess diverse roles in multiple cellular compartments, challenging traditional localization paradigms.
  • This widespread protein plasticity has significant implications for understanding cellular evolution and organization.
  • Understanding these non-canonical protein functions is crucial for investigating diseases such as Alzheimer's disease and cancer.