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Prediction of the three-dimensional structure of human interleukin-7 by homology modeling
R T Kroemer1, S W Doughty, A J Robinson
1Physical and Theoretical Chemistry Laboratory, University of Oxford, UK.
Protein Engineering
|June 1, 1996
Abstract:
The three-dimensional structure of human interleukin (IL)-7 has been predicted based on homology to human IL-2, IL-4, granulocyte-macrophage colony stimulating factor and growth hormone. The model has a topology common to other cytokines and displays a unique disulfide pattern. Knowledge of the tertiary structure of IL-7 has implications for analysis of key binding regions, suggestions for mutagenesis experiments and design of (ant)agonists. In this context, the model is discussed and compared with other cytokine structures.