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Related Experiment Videos

Meal frequency; does it determine postprandial lipaemia?

M C Murphy1, C Chapman, J A Lovegrove

  • 1Nutrition Research Group, School of Biological Sciences, University of Surrey, Guildford, UK.

European Journal of Clinical Nutrition
|August 1, 1996
PubMed
Summary
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Altering meal frequency did not significantly change fasting or postprandial lipid and hormone levels in young women. Previous studies suggesting benefits of nibbling may be due to uncontrolled nutrient intake.

Area of Science:

  • Nutrition Science
  • Metabolic Studies
  • Dietary Interventions

Background:

  • Meal frequency is a key dietary behavior with potential metabolic implications.
  • Previous research suggested that 'nibbling' (frequent small meals) may offer metabolic benefits over 'gorging' (fewer large meals).
  • However, the impact of controlled meal frequency on postprandial lipaemia and hormonal responses requires further investigation.

Purpose of the Study:

  • To investigate the effects of two weeks of altered meal frequency (nibbling vs. gorging) on postprandial lipaemia and associated metabolic parameters.
  • To compare the metabolic responses to a standard high-fat meal after distinct dietary patterns.

Main Methods:

  • A randomized open cross-over study involving eleven healthy female volunteers.

Related Experiment Videos

  • Participants followed either a 'nibbling' (12 meals/day) or 'gorging' (3 meals/day) diet for two weeks, with a washout period in between.
  • Standardized high-fat test meals were administered, and blood samples were analyzed for lipids, glucose, insulin, GIP, GLP-1, and postheparin lipoprotein lipase (LPL) activity. Gastric emptying was assessed using paracetamol absorption.

    • Main Results:

    • High compliance was observed for both dietary regimens with no significant differences in overall nutrient intake.
    • No significant differences were found in fasting or postprandial plasma concentrations of triacylglycerol, non-esterified fatty acids, glucose, insulin, GIP, or GLP-1 between the nibbling and gorging diets.
    • While HDL-cholesterol significantly increased following the gorging diet compared to nibbling, other lipid parameters and LPL activity showed no significant changes.

    Conclusions:

    • Two weeks of altered meal frequency (nibbling vs. gorging) did not significantly impact fasting or postprandial lipid or hormonal responses to a high-fat meal in young, healthy women.
    • The findings challenge previous suggestions that nibbling is metabolically superior, indicating that rigorous control of diet composition in this study may have revealed that reported effects in prior studies were due to confounding variations in nutrient and energy intake.